Human anti-factor ix/ixa antibodies

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) C07K 16/40 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2341276

Human antibodies, or fragments thereof, to the gamma-carboxyglutamic acid (Gla) domain of factor IX and factor IXa, especially of human factor IX and human factor IXa. Isolated nucleic acid encoding said antibodies or fragments thereof. Methods for their preparation. Pharmaceutical composition comprising said antibodies or fragments thereof, and a method for treating a mammal by using said pharmaceutical composition in a therapeutically effective amount.

L'invention concerne des anticorps humains, ou des fragments de ces anticorps, dirigés contre le domaine acide gamma-carboxyglutamique (Gla) du facteur IX et du facteur IXa, notamment des facteurs IX et IXa humains. L'invention concerne également des acides nucléiques isolés codant pour lesdits anticorps ou leurs fragments, des techniques de préparation de ces anticorps, une composition pharmaceutique renfermant lesdits anticorps ou des fragments de ceux-ci, ainsi qu'une méthode de traitement d'un mammifère utilisant ladite composition pharmaceutique en quantités thérapeutiquement efficaces.

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