Human anti-mesothelin monoclonal antibodies

Details Human anti-mesothelin monoclonal antibodies Human anti-mesothelin monoclonal antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61P 35/00 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2718321

Disclosed herein are isolated human monoclonal antibodies that specifically bind human mesothelin with a binding affinity of about 25 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect human mesothelin in a sample. Methods of diagnosing cancer, or confirming a diagnosis of cancer, are disclosed herein that utilize these antibodies. Methods of treating a subject with cancer are also disclosed.

Les anticorps monoclonaux humains isolés ci-décrits se lient spécifiquement à la mésothéline humaine à une affinité de liaison d'environ 25 nM ou moins. Des acides nucléiques codant pour ces anticorps, des vecteurs d'expression comprenant ces molécules d'acides nucléiques, et des cellules-hôtes isolées qui expriment les molécules d'acides nucléiques sont également décrits. Les anticorps peuvent être utilisés pour détecter la mésothéline humaine dans un échantillon. Des procédés de diagnostic du cancer, ou de confirmation d'un diagnostic de cancer qui utilisent ces anticorps sont décrits. Des procédés pour traiter un sujet atteint du cancer sont également décrits.

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