Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor

Details Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2738252

The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

La présente invention se base, en partie, sur l'identification de nouveaux anticorps anti-PD-1, PD-L1, et PD-L2 humains. Par conséquent, cette invention concerne des compositions et des procédés pour diagnostiquer, pronostiquer, et traiter des affections qui bénéficieraient d'une modulation de l'activité PD-1, PD-L1, et/ou PD-L2 (par exemple, maladies infectieuses persistantes, maladies auto-immunes, asthme, rejet de greffe, troubles inflammatoires et tumeurs) exercée par les nouveaux anticorps anti-PD-1, PD-L1, et PD-L2 humains ci-décrits.

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