C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2116888
Human monoclonal antibodies (mAbs) which bind to human TNF.alpha. Autoantibodies of both the IgM and IgG isotypes are disclosed. A preferred human monoclonal antibody is known as B5 (F78-1A10-B5 mAb) and it binds to recombinant human TNF.alpha. (rhTNF.alpha.) in ELISA format with a titer comparable to three high affinity neutralizing mouse mAbs. It also binds to cell surface TNF.alpha. and prevents TNF.alpha. secretion by human monocyte cell lines.
Boyle Petra
Lembach Kenneth J.
Wetzel Gayle D.
Corporation Bayer
Miles Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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