C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2401342
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determing regions (CDRs) of the CAT-212/-213 VH and/or VL domains, especially VH CRD3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralising eotaxin, including methods of treatment of the human or animal body by therapy.
L'invention concerne des éléments de liaison spécifiques dirigés contre l'éotaxine-1, en particulier les anticorps et les fragments d'anticorps humains contre l'éotaxine-1 humaine et surtout ceux qui neutralisent l'activité de l'éotaxine-1. L'anticorps du domaine VH et/ou Vl du fragment scFv désigné ici CAT-212 et l'anticorps IgG4 désigné ici CAT-213. L'invention concerne au moins une région de détermination de complémentarité (CDRs) des domaines CAT-212/-213 VH et/ou VL, surtout VH CDR3 dans d'autres régions d'infrastructure d'anticorps. L'invention concerne également des compositions renfermant des éléments de liaisons spécifiques, l'utilisation associée dans des méthodes d'inhibition ou de neutralisation d'éotaxine, notamment des méthodes de traitement du corps humain ou animal par thérapie.
Main Sarah Helen
Smith Stephen
Vaughan Tristan John
Wilton Alison Jane
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cambridge Antibody Technology Limited
Medimmune Limited
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