C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/10 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2678888
Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
L'invention concerne des anticorps monoclonaux humains isolés qui se lient au virus de l'hépatite C (VHC) ainsi que des compositions et des molécules à base d'anticorps en découlant. Les anticorps humains peuvent être produits dans un transfectome ou dans un animal transgénique non humain, par exemple une souris transgénique, capables de produire des isotypes multiples d'anticorps monoclonaux humains par recombinaison V-D-J et échange d'isotypes. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps humains, des animaux transgéniques non humains et des hybridomes qui produisent les anticorps humains, ainsi que des procédés thérapeutiques et diagnostiqueditss pour utiliser les anticorps humains.
Ambrosino Donna
Babcock Gregory J.
Broering Teresa
Sloan Susan
Thomas William D. Jr.
Osler Hoskin & Harcourt Llp
University Of Massachusetts
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