Human antibodies against human glycoprotein vi and their use

Details Human antibodies against human glycoprotein vi and their use Human antibodies against human glycoprotein vi and their use

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2510745

Specific binding members directed to human glycoprotein VI (GPVI), in particular human antibodies, may employ the antibody VH and/or VL domain of the scFv fragment herein termed 10B12 or one or more complementarity determining regions (CDRs) of the 10B12 heavy chain variable (VH) and/or light chain variable (VL) domains, especially VH CDR3 in other antibody framework regions. Antibody molecules are provided with advantageous and unexpected properties, especially ability to inhibit collagen-induced platelet aggregation and the adhesion of platelets to Collagen-Related Peptide (CRP). Domain 1 of human GPVI is a primary target for the 10B12 antibody with these properties, and the epitope includes lysine 59.

Des éléments de liaison spécifiques dirigés contrer la glycoprotéine VI humaine (GPVI), en particulier des anticorps humains, peuvent utiliser le domaine anticorps VH et/ou VL du fragment scFv, dit 10B12, ou une ou plusieurs régions déterminantes complémentaires des domaines de 102B12 à variable à chaîne lourde (VH) et/ou à chaîne légère (VL), en particulier VH CDR3, dans d'autres régions structurales d'anticorps. L'invention concerne des molécules d'anticorps présentant des propriétés avantageuses et inattendues, en particulier l'aptitude à inhiber une agrégation des plaquettes induites par le collagène et l'adhésion de plaquettes à un peptide associé au collagène. Le domaine 1 de la glycoprotéine GPVI humaine constitue une cible principale de l'anticorps 10B12 doté de ces propriétés, et l'épitope comprend la lysine 59.

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