Human antibodies against varicella-zoster virus

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/42 (2006.01) C07K 16/08 (2006.01) C07K 16/10 (2006.01) C12N 5/10 (2006.01) C12N 5/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2168230

The invention provides human monoclonal antibodies specific for the glycoprotein II subunit of Varicella-zoster virus. Preferred antibodies exhibit strong complement-independent neutralizing activity, antibody dependent cellular cytotoxicity, and cross-reactivity with multiple strains of Varicella-zoster virus.

L'invention porte sur des anticorps humains monoclonaux spécifiques de la sous-unité de la glycoprotéine II du virus varicelle-zona. Les anticorps préférés présentent une forte activité neutralisante indépendante du complément, une cytoxicité cellulaire dépendant de l'anticorps et une réactivité croisée avec de nombreuses souches du virus varicelle-zona.

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