Human antibodies and proteins

Details Human antibodies and proteins Human antibodies and proteins

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 14/18 (2006.01) C07K 14/415 (2006.01) C07K 14/815 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2596833

The present invention provides composite proteins, including antibodies, which show reduced immunogenicity. In particular, composite antibodies for use in humans are provided, in particular antibodies which have been modified to remove one or more T-cell epitopes. Methods for generating such proteins are also provided.

La présente invention porte sur des protéines composites, telles que des anticorps, qui présentent une immunogénicité réduite. L'invention porte, notamment, sur des anticorps composites destinés à être utilisés chez l'homme, et en particulier des anticorps qui ont été modifiés pour éliminer un ou plusieurs épitopes des lymphocytes T. L'invention porte également sur des procédés de génération de ces protéines.

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