Human antibodies as detection reagents

Details Human antibodies as detection reagents Human antibodies as detection reagents

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2392729

The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the sample. The methods can be effected using a sandwich format among others.

L'invention concerne des méthodes de détection in vitro utilisant des anticorps humains. Les méthodes sont particulièrement utiles pour analyser des échantillons humains contenant des anticorps anti-souris (HAMA) ou des anticorps hétérophiles. Un anticorps humain peut se fixer à un analyte dans ces échantillons sans se fixer au HAMA ou à des anticorps hétérophiles présents dans l'échantillon. Les méthodes peuvent être exécutées à l'aide d'un format en sandwich entre autres.

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