Human antibodies derived from immunized xenomice

Details Human antibodies derived from immunized xenomice Human antibodies derived from immunized xenomice

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/16 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2761116

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.

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