Human antibodies derived from immunized xenomice

Details Human antibodies derived from immunized xenomice Human antibodies derived from immunized xenomice

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/00 (2006.01) C12P 21/08 (2006.01) A61K 39/395 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2219361

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.

Des anticorps intégralement humains contre un antigène spécifique peuvent être préparés par administration de l'antigène à un animal transgénique qui a été modifié pour produire de tels anticorps en réaction à une provocation antigénique, mais dont les emplacement endogènes ont été invalidés. La réalisation de diverses manipulations ultérieures permet d'obtenir des anticorps en soi ou leurs analogues.

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