Human antibodies specific for interleukin 15 (il-15)

Details Human antibodies specific for interleukin 15 (il-15) Human antibodies specific for interleukin 15 (il-15)

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 17/06 (2006.01)

Patent

CA 2516378

Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non- human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Anticorps monoclonaux humains isolés qui se lient spécifiquement à l'interleukine 15 (IL-15) (par exemple l'IL-15 humaine), et des molécules et compositions à base d'anticorps associées. Les anticorps humains peuvent être produits dans un transfectome ou dans un animal transgénique non humain, par exemple une souris transgénique, apte à produire des isotypes multiples d'anticorps monoclonaux humains par recombinaison V-D-J et échange d'isotypes. On décrit également des compositions pharmaceutiques comportant les anticorps humains, des animaux transgéniques non humains, et des hybridomes qui produisent les anticorps humains, ainsi que des procédés thérapeutiques et diagnostiques mettant en oeuvre les anticorps humains.

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