C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) C07K 14/47 (2006.01) C07K 16/24 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01) C12N 5/18 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01)
Patent
CA 2456648
Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non- human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
La présente invention concerne des anticorps monoclonaux humains isolés qui se lient de manière spécifique à IL-15 (par exemple, IL-15 humaine) et des compositions et des molécules à base d'anticorps correspondants. Les anticorps humains peuvent être produits dans un 'transfectome'' ou dans un animal transgénique non humain, par exemple, une souris transgénique, capable de produire plusieurs isotypes d'anticorps monoclonaux humains par recombinaison V-D-J et commutation isotypique. Cette invention concerne également les anticorps humains, des animaux transgéniques non humains et des hybridomes qui produisent les anticorps humains, ainsi que des méthodes de thérapie et de diagnostic dans lesquelles on utilise les anticorps humains.
Baadsgaard Ole
Gerritsen Arnout F.
Schuurman Janine
Van de Winkel Jan G. J.
Van Dijk Marcus Antonius
Genmab A/s
Gowling Lafleur Henderson Llp
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