Human antibodies that bind cd19 and uses thereof

Details Human antibodies that bind cd19 and uses thereof Human antibodies that bind cd19 and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2672800

The present disclosure provides isolated monoclonal antibodies that specifically bind to CD 19 with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human CD 19. In certain embodiments, the antibodies are capable of internalizing into CD19-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD 19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas of B lineage, and multiple myelomas using an anti-CD 19 antibody of this disclosure.

L'invention concerne des anticorps monoclonaux isolés qui se lient spécifiquement à CD 19 avec une forte affinité, en particulier des anticorps monoclonaux humains. De préférence, ces anticorps se lient à CD 19. Dans certaines formes de réalisation, ces anticorps sont capables de s'internaliser dans les cellules exprimant CD19 ou d'induire une cytotoxicité cellulaire dépendant des antigènes. L'invention concerne aussi des molécules d'acide nucléique codant pour ces anticorps, des vecteurs d'expression, des cellules hôtes et des procédés d'expression de ces anticorps; et des conjugués anticorps-molécule partenaire, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de l'invention; des procédés de détection de CD 19 et des méthodes utilisant un anticorps anti-CD 19 de l'invention pour traiter des cancers tels que des tumeurs malignes lymphoïdes, par exemple, un lymphome non hodgkinien, des leucémies lymphocytaires chroniques, des lymphomes folliculaires, des lymphomes diffus à grandes cellules B et des myélomes multiples.

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