Human antibodies that bind cd22 and uses thereof

Details Human antibodies that bind cd22 and uses thereof Human antibodies that bind cd22 and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2671457

The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody- partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.

L'invention concerne des anticorps monoclonaux isolés présentant une affinité élevée pour se lier spécifiquement à CD22, en particulier à des anticorps monoclonaux humains. L'invention propose également des molécules d'acide nucléique codant les anticorps de cette révélation, des vecteurs d'expression, des cellules hôtes et des procédés pour exprimer les anticorps de cette révélation. Des conjugués anticorps-molécules partenaires, des molécules biospécifiques et des compositions pharmaceutiques comprenant les anticorps décrits dans la présente invention sont également proposés. La présente invention propose de plus des procédés de détection le CD22 ainsi que des procédés de traitement de divers cancers et de troubles inflammatoires et auto-immunitaires utilisant l'anticorps anti-CD22 décrit dans la présente invention.

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