Human antibodies that bind cd70 and uses thereof

Details Human antibodies that bind cd70 and uses thereof Human antibodies that bind cd70 and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2672468

The present disclosure provides isolated monoclonal antibodies that specifically bind to CD70 with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human CD70. In certain embodiments, the antibodies are capable of being internalized into CD70-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD70, as well as methods for treating cancers, such as renal cancer and lymphomas, using an anti-CD7Q antibody of this disclosure.

La présente invention concerne des anticorps monoclonaux isolés qui se lient spécifiquement à CD70 avec une grande affinité, en particulier des anticorps monoclonaux humains. De préférence, lesdits anticorps se lient à CD70 humain. Dans certains modes de réalisation, ces anticorps sont capables d'être internalisés dans des cellules exprimant CD70 ou sont capables d'induire la cytotoxicité cellulaire dépendante des antigènes. La présente invention concerne également des molécules d'acide nucléique codant pour les anticorps de la présente invention, des vecteurs d'expression, des cellules hôtes et des procédés destinés à exprimer les anticorps de l'invention. L'invention concerne en outre des conjugués de molécules partenaires d'anticorps, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de la présente invention. L'invention concerne enfin des procédés de détection de CD70, ainsi que des procédés de traitement de cancers, tels que le cancer du rein et les lymphomes, utilisant un anticorps anti-CD70 de cette invention.

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