Human antibodies that bind cxcr4 and uses thereof

Details Human antibodies that bind cxcr4 and uses thereof Human antibodies that bind cxcr4 and uses thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2665239

The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.

La présente invention fournit des anticorps monoclonaux isolés qui se lient spécifiquement au CXCR4 avec une affinité élevée, en particulier des anticorps monoclonaux humains. Des molécules d'acide nucléique codant pour les anticorps de cette description, des vecteurs d'expression, des cellules hôtes et des procédés pour exprimer les anticorps de cette description sont également fournis. Des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de cette description sont également fournis. Cette description fournit également des procédés pour détecter le CXCR4, de même que des procédés pour traiter divers cancers, des troubles inflammatoires et une infection VIH, en utilisant un anticorps anti-CXCR4 de cette description.

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