Human antibodies that bind human il-12 and methods for...

Details Human antibodies that bind human il-12 and methods for... Human antibodies that bind human il-12 and methods for...

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 43/00 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2365281

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

On décrit des anticorps humains, de préférence des anticorps humains de recombinaison qui se lient de manière spécifique à l'interleukine-12 humaine (hIL-12). Les anticorps préférés présentent une forte affinité pour hIL-12 et neutralisent l'activité hIL-12 in vitro et in vivo. Un anticorps selon la présente invention peut être un anticorps entier ou une partie de liaison d'antigène de ce dernier. Les anticorps ou les parties d'anticorps de cette invention sont utiles pour détecter hIL-12 et pour inhiber l'activité hIL-12, par exemple chez un patient humain souffrant d'une maladie dans laquelle l'activité hIL-12 est préjudiciable. On décrit également des acides nucléiques, des vecteurs et des cellules hôtes qui permettent d'exprimer les anticorps humains selon la présente invention ainsi que des procédés de synthèse desdits anticorps humains de recombinaison.

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