Human antibodies that bind human il-12 and methods for...

Details Human antibodies that bind human il-12 and methods for... Human antibodies that bind human il-12 and methods for...

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 8/18 (2006.01) A61K 39/395 (2006.01) C07K 1/113 (2006.01) C07K 14/54 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2673639

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

L'invention concerne des anticorps humains, de préférence des anticorps humain recombinants, qui se lient spécifiquement à l'interleukine-12 humaine (hIL-12). Les anticorps préférés présentent une grande affinité pour hIL-12 et neutralisent l'activité de hIL-12 in vitro et in vivo. Un anticorps selon l'invention peut être un anticorps de pleine longueur ou une partie de cet anticorps se liant à un antigène. Les anticorps, ou les parties d'anticorps, selon l'invention sont utiles pour détecter hIL-12 et pour inhiber l'activité de hIL-12, p. ex. chez un sujet humain souffrant d'un trouble pour lequel l'activité de hIL-12 est néfaste. L'invention concerne également des acides nucléiques, des vecteurs et des cellules hôtes permettant d'exprimer les anticorps humains recombinants selon l'invention, ainsi que des procédés de synthèse des anticorps humains recombinants.

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