Human antibodies to human cd20 and method of using thereof

Details Human antibodies to human cd20 and method of using thereof Human antibodies to human cd20 and method of using thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2695199

A human antibody or antigen-binding fragment of an antibody that specifically binds human CD20 and is capable of inducing complement dependent cytotoxicity (CDC), and is capable of increasing symptom free survival time between about 2-fold to about 9-fold or more, relative to control-treated animals in a mouse model of human lymphoma. The antibody or antigen--binding fragment thereof is useful in a therapeutic method for treating a CD20-mediated disease or condition, such as for example, non-Hodgkin's lymphoma, rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, chronic lymphocytic leukemia, and inflammatory diseases.

L'invention concerne un anticorps humain ou un fragment de liaison à un antigène d'un anticorps qui se lie spécifiquement au CD20 humain et est apte à induire une cytotoxicité dépendante de complément (CDC) et à multiplier le temps de survie sans symptôme par 2 à environ 9 ou plus que chez des animaux témoins traités dans un modèle de souris de lymphome humain. L'anticorps ou son fragment de liaison à un antigène est utile dans le procédé thérapeutique d'une maladie ou affection véhiculée par CD20 telle que, par exemple, le lymphome non hodgkinien, la polyarthrite rhumatoïde, le lupus érythémateux systémique, la maladie de Crohn, la leucémie lymphocytaire chronique et les maladies inflammatoires.

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