Human antibodies to human delta like ligand 4

Details Human antibodies to human delta like ligand 4 Human antibodies to human delta like ligand 4

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2672622

An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti- hDII4 antibody or antibody fragment binds hDII4 with an affinity of <= 500 pM, as measured by surface plasmon resonance.

L'invention concerne un anticorps humain isolé ou un fragment d'un anticorps humain qui se lie spécifiquement au ligand Delta-4 humain (hDII4) et bloque la liaison de hDII4 à un récepteur Notch. L'anticorps humain anti-hDII4 ou le fragment d'anticorps se lie à hDII4 avec une affinité <= 500 pM, telle que mesurée par résonance de plasmon de surface.

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