C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A01K 67/027 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/20 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2373221
Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to one or more <i>S. aureus</i> strains, including methicillin resistant <i>S. aureus</i> strains, are disclosed. The human antibodies can be produced in a non-human transgenic animal, <i>e.g.</i>, a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non- human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
L'invention concerne des anticorps monoclonaux humains isolés et des portions de ceux-ci, de liaison à des antigènes, se liant spécifiquement à une ou plusieurs souches de <i>S. aureus</i>, y compris des souches <i>S. aureus</i> résistant à la méthicilline. Les anticorps humains peuvent être produits dans un animal transgénique non humain, par exemple, une souris transgénique, capable de produire de multiples isotypes d'anticorps monoclonaux humains par recombinaison V-D-J et commutation isotype. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps humains, des animaux transgéniques non humains et des hybridomes produisant les anticorps humains. Enfin, l'invention concerne des procédés thérapeutiques et de diagnostic pour l'utilisation des anticorps humains.
Deo Yashwant M.
Keler Tibor
Borden Ladner Gervais Llp
Medarex Inc.
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