Human antihuman interleukin-6 antibody and fragment of the...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2496523

It is intended to provide a substance efficacious in treating an immunopathy in which interleukin-6 (IL-6) participates. Using the phage antibody method, a human antihuman IL-6 antibody and a human antihuman IL-6 antibody fragment showing a high affinity for human IL-6 are obtained. The above antibody and antibody fragment are expected as being useful as remedies for inflammation and an immunopathy caused by IL-6.

L'invention concerne une substance efficace pour traiter une immunopathie provoquée par l'interleukine-6 (IL-6). En utilisant le procédé d'anticorps de phage, on a pu obtenir un anticorps d'interleukine-6 antihumaine de type humain et un fragment de l'anticorps d'interleukine-6 antihumaine de type humain manifestant une affinité élevée pour l'interleukine-6 antihumaine. On s'attend à ce que l'anticorps et le fragment d'anticorps de l'invention soient utiles en tant que remèdes pour l'inflammation et l'immunopathie provoquées par l'interleukine-6.

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