Human bad polypeptides, encoding nucleic acids and methods...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2265912

The invention provides an isolated gene and an isolated nucleic acid sequence encoding human Bad and functional fragments thereof. Also provided is an isolated human Bad polypeptide and functional fragments thereof. Methods of identifying human Bad binding partners and methods of screening for compounds which interfere with the association of human Bad interacting polypeptides with human Bad are also provided. Finally, methods for decreasing or increasing the viability of a cell are provided as well.

L'invention concerne un gène isolé et une séquence nucléotidique isolée codant une Bad (mort associée Bcl-xL/Bcl-2) humaine et des fragments fonctionnels afférents. L'invention concerne également un polypeptide de Bad humaine isolé et des fragments fonctionnels de celui-ci, des procédés d'identification de partenaires de liaison de Bad humaine et des procédés de criblage de composés qui interférent avec l'association avec une Bad humaine de polypeptides d'interaction avec une Bad humaine. Enfin, l'invention concerne des procédés de diminution ou d'augmentation de la viabilité d'une cellule.

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