Human beta-trcp protein

Details Human beta-trcp protein Human beta-trcp protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/70 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2370098

The present invention relates to the human .beta.TrCP protein for the targeting of proteins towards proteasome degradation pathways, which is capable of interacting with the Vpu protein of HIV-1 virus, with the cell proteins I.kappa.B and .beta.--catenin and with the cell protein Skp1p, to its peptide fragments and to the nucleic acid sequences coding for said protein and its fragments. It further relates to the use of the human .beta.TrCP protein or its peptide fragments for the screening of anti-HIV-1 antiviral agents, antitumoral agents and anti-inflammatory agents, to the antiviral agents, antitumoral agents and anti- -inflammatory agents, and to the antibodies directed against said protein and its peptide fragments.

La présente invention concerne la protéine humaine beta -TrCP de ciblage des protéines vers les voies de dégradation par le protéasome qui est capable d'interagir avec la protéine Vpu du virus HIV-1, avec les protéines cellulaires I kappa B et beta -caténine et avec la protéine cellulaire Skp1p, ainsi que ses fragments peptidiques et les séquences d'acides nucléiques codant pour ladite protéine et ses fragments. Elle concerne également l'utilisation de la protéine humaine beta -TrCP ou de ses fragments peptidiques pour le criblage d'agents antiviraux anti-HIV-1, et d'agents antitumoraux et d'agents anti-inflammatoires, les agents antiviraux, les agents antitumoraux, les agents anti-inflammatoires et les anticorps dirigés contre ladite protéine et ses fragments peptidiques.

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