Human binding molecules capable of neutralizing influenza...

Details Human binding molecules capable of neutralizing influenza... Human binding molecules capable of neutralizing influenza...

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/42 (2006.01)

Patent

CA 2761648

The present invention relates to binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. In a preferred embodiment, the antibodies provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.

La présente invention concerne des molécules de liaison, telles que des anticorps monoclonaux humains, qui se lient à un virus de la grippe comportant une protéine HA du sous-type H3, tel que H3N2, et qui présentent une large activité de neutralisation envers un tel virus de la grippe. L'invention concerne des molécules d'acide nucléique codant pour les anticorps, leurs séquences et les compositions comportant les anticorps et les procédés d'identification ou de production des anticorps. Les anticorps peuvent être utilisés dans le diagnostic, la prophylaxie et/ou le traitement d'une infection à virus de la grippe H3N2. Dans un mode de réalisation préféré, les anticorps confèrent une protection à sous-type croisé, de sorte que les infections avec des sous-types de la grippe à base de H3, H7 et/ou H10 peuvent être prévenues et/ou traitées.

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