Human bocavirus and methods of diagnosis and treatment

Details Human bocavirus and methods of diagnosis and treatment Human bocavirus and methods of diagnosis and treatment

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 39/23 (2006.01) A61K 48/00 (2006.01) C07K 14/015 (2006.01) C07K 16/08 (2006.01) C12N 15/35 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2629786

Human parvovirus, genus Bocavirus, associated with respiratory tract infections in children. Nucleic acid and polypeptide sequences of the virus. Methods and products for diagnosing presence of bocavirus in a sample using nucleic acid probes or primers, or specific binding members such as antibodies. Methods and products for diagnosing past or present infection of bocavirus in an individual e.g. by serology testing. Viral nucleic acid, polypeptide and/or viral particles for generating immune response in an individual, including vaccine compositions.

La présente invention concerne un parvovirus humain du genre Bocavirus, associé à des infections des voies respiratoires chez les enfants. L'invention concerne des séquences d'acide nucléique et des séquences polypeptidiques du virus, ainsi que des procédés et des produits permettant de diagnostiquer la présence de Bocavirus dans un échantillon à l'aide de d'amorces ou de sondes d'acide nucléique ou d'éléments de liaison spécifiques tels que des anticorps. L'invention concerne également des procédés et des produits permettant de diagnostiquer une infection présente ou passée de Bocavirus chez un individu, à l'aide d'un test sérologique par exemple. L'invention concerne enfin un acide nucléique viral, un polypeptide et/ou des particules virales qui provoquent une réponse immune chez un individu, y compris des compositions vaccinales.

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