Human c-fms antigen binding proteins

Details Human c-fms antigen binding proteins Human c-fms antigen binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2696761

Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-I, reduce monocyte migration into tumors, and reduce the accumulation of tumor- associated macrophages.

L'invention porte sur des protéines de liaison à un antigène qui se lient à la protéine de c-fms humain. L'invention porte également sur des acides nucléiques codant pour la protéine de liaison à un antigène, des vecteurs et des cellules codant pour ceux-ci. Les protéines de liaison à un antigène peuvent inhiber à la liaison de c-fms à CSF-I, réduire une migration des monocytes dans les tumeurs, et réduire l'accumulation de macrophages associés aux tumeurs.

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