Human cachexia associated protein

Details Human cachexia associated protein Human cachexia associated protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250868

The present invention provides a polynucleotide (The upper and lower cases are to be respected as per the original abstract) isolated from a breast tumor library which identifies and encodes a human cachexia-associated protein (HCAP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HCAP. The invention also provides for the therapeutic use of purified HCAP in the treatment of severe or moderate obesity, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of tumor-induced cachexia. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.

Polynucléotide (The upper and lower cases are to be respected) isolé à partir d'une génothèque de tumeurs du sein identifiant et codant une protéine (HCAP) associée à la cachexie chez l'être humain. L'invention porte sur des cellules hôtes et sur des vecteurs d'expression qui ont été manipulés génétiquement et qui renferment la séquence d'acide nucléique codant la HCAP. L'invention porte également sur l'utilisation thérapeutique de la HCAP purifiée pour le traitement de l'obésité grave ou modérée et sur l'utilisation thérapeutique de molécules, d'anticorps, d'antagonistes ou d'inhibiteurs antisens pour le traitement de la cachexie induite par tumeur. L'invention porte également sur des méthodes diagnostiques mettant en oeuvre des compositions de diagnostic renfermant ce polynucléotide ou des fragments de ce polynucléotide, ou des anticorps qui se lient spécifiquement à ce polypeptide.

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