A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/129, 167/139
A61K 39/00 (2006.01) C07K 16/30 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01)
Patent
CA 1083037
ABSTRACT OF THE DISCLOSURE A novel human cancer associated protein, termed Cl 1AC, having Cl inactivator-like function has been provided. Diag- nostic tests based on demonstrating the presence of Cl 1AC have also been provided. In addition, antibodies and anti- sera with specificity against Cl 1AC have been discovered. Matrix-immobilized antibodies have also been discovered. The Cl 1AC is preferably prepared by immunizing a non-human animal against an .alpha.-neuramino glycoprotein having inhibitory activity upon Cl esterase hydrolyizing effect, and inhibitory effect on Cl activation of C4 as shown by the inhibition of complement haemolysis, which process comprises: immunizing a non-human animal against the said .alpha.-neuramino glycoprotein; and then harvesting serum from the immunized animal. The invention also provides a therapy of human cancer using antisera or anitbodies with specificity against Cl 1AC: A novel human cancer associated protein; termed CAAC, and antisera and anti- bodies with specificity against CAAC have also been discovered. The used of rabbit antihuman C4 is also provided for monitoring cancer diseases.
238553
Benzon Pharma A/s
Marcus & Associates
LandOfFree
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