Human cardiac/brain tolloid-like protein

Details Human cardiac/brain tolloid-like protein Human cardiac/brain tolloid-like protein

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) C07K 14/51 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2219265

HC/BTLP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hC/BTLP polypeptides and polynucleotides in the design of protocols for the treatment of restenosis, atherosclerosis, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), benign prostatic hypertrophy (BPH), nephritis, fibrosis, glomerulonephritis, gliosis, cirrhosis and anomalies of wound healing, such as keloids among others, and diagnostic assays for such conditions.

Sont décrits ici des polynucléotides et des polypeptides HC/BTLP et des méthodes de production de ces polypeptides par des techniques de l'ADN recombinant. Sont également décrites des méthodes d'utilisation des polynucléotides et des polypeptides HC/BTLP dans la conception de protocole pour le traitement de diverses affections (resténose, athérosclérose, insuffisance cardiaque globale, bronchopneumopathie chronique obstructive (BPCO), hypertrophie prostatique bénigne, néphrite, fibrose, glomérulonéphrite, gliose, cirrhose et anomalies de la cicatrisation, notamment chéloïdes), ainsi que d'épreuves diagnostiques pour ces affections.

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