Human ccn-like growth factor

Details Human ccn-like growth factor Human ccn-like growth factor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2220912

A human Small CCN-like Growth Factor polypeptide (SCGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonists against such polypeptides and their use as a therapeutic to treat atherosclerosis, tumors and scarring are also disclosed. Diagnostic assays for identifying mutations in SCGF nucleic acid sequence and altered levels of the SCGF polypeptide are also disclosed.

L'invention porte sur un petit polypeptide qui est un facteur de croissance humain du type CCN, appelé également polypeptide SCGF, ainsi que l'ADN (ARN) codant pour ce polypeptide et un procédé pour produire ce polypeptide par des techniques de recombinaison. L'invention porte également sur des méthodes d'utilisation de ces polypeptides pour la cicatrisation de blessures ou la régénération de tissus, la stimulation de la fixation d'implants et l'angiogenèse. L'invention porte également sur des antagonistes de ces polypeptides et leur utilisation pour traiter l'athérosclérose, les tumeurs et les cicatrices. L'invention porte également sur des tests diagnostiques permettant d'identifier des mutations dans la séquence des acides nucléiques codant pour le polypeptide SCGF, et de déceler les modifications des niveaux du polypeptide SCGF.

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