Human cdr-grafted antibody and antibody fragment thereof

Details Human cdr-grafted antibody and antibody fragment thereof Human cdr-grafted antibody and antibody fragment thereof

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2458627

A human CDR-grafted antibody which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but shows no reactivity with human platelets or its antibody fragment; a human CDR-grafted antibody which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) and shows cytotoxicity on cells expressing CCR4 or its antibody fragment; and drugs, remedies and diagnostics containing at least one member selected from these antibodies and antibody fragments as the active ingredient.

Cette invention concerne : un anticorps greffé CDR humain réagissant spécifiquement avec la région extracellulaire du récepteur 4 (CCR4) de la chimiokine CC d'origine humaine, mais ne montre aucune réactivité à l'égard des plaquettes humaines ou de son fragment d'anticorps ; un anticorps greffé CDR humain réagissant spécifiquement avec la région extracellulaire du récepteur 4 (CCR4) de la chimiokine CC d'origine humaine qui présente une cytotoxicité pour les cellules exprimant CCR4 ou son fragment d'anticorps. L'invention concerne également des médicaments, remèdes et ensembles diagnostiques comprenant comme principe actif au moins un élément pris parmi ces anticorps et fragments d'anticorps.

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