Human cell line showing stable expression of cytochromes p450

Details Human cell line showing stable expression of cytochromes p450 Human cell line showing stable expression of cytochromes p450

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 45/00 (2006.01) A61P 1/16 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2370365

A cell line obtained from a human liver-origin incubated cell line as a host and showing stable expression of a number of human cytochromes P450, etc. Because of showing stable expression of human cytochromes P450 CYP1A1, 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4, the human liver-origin incubated cell line is useful in, for example, analyzing an enzyme participating in the metabolism of a foreign matter in vivo or an endogenous substrate.

L'invention se rapporte à une lignée cellulaire provenant d'une lignée cellulaire incubée, d'origine hépatique humaine, qui est utilisée en tant qu'hôte et présente une expression stable d'un certain nombre de cytochromes humains p450, etc. En raison de cette stabilité d'expression des cytochromes humains P450 CYP1A1, 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 et 3A4, cette lignée cellulaire incubée, d'origine hépatique humaine, s'avère utile pour l'analyse, par exemple, d'une enzyme participant au métabolisme d'une matière étrangère in vivo ou d'un substrat endogène.

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