Human cervical cancer suppressor protein, polynucleotide...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2405983

The present invention provides a human tumor suppressor protein having the amino acid sequence of SEQ ID NO: 2; a polynucleotide encoding the tumor suppressor protein; an expression vector containing the polynucleotide; a microorganism or animal cell transformed with the expression vector; a method for suppressing proliferation of a cancer cell which comprises introducing the expression vector into a cancer cell to induce apoptosis thereof; and a pharmaceutical composition for preventing or treating cancer which comprises a therapeutically effective amount of the polynucleotide and a pharmaceutically acceptable carrier.

La présente invention concerne une protéine suppressive de tumeur humaine possédant la séquence d'acides aminés de SEQ ID NO : 2 ; un polynucléotide codant pour ladite protéine suppressive ; un vecteur d'expression contenant le polynucléotide ; un micro-organisme ou une cellule animale transformés à l'aide du vecteur d'expression ; une méthode de suppression de la prolifération d'une cellule cancéreuse consistant à introduire le vecteur d'expression dans une cellule cancéreuse afin de provoquer son apoptose ; et une composition pharmaceutique servant à prévenir ou à traiter un cancer, constituée d'une dose du polynucléotide efficace d'un point de vue thérapeutique et d'un excipient pharmaceutiquement acceptable.

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