C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2317810
An isolated chemokine is disclosed. The isolated chemokine is expressed preferentially in breast tissue or can be detected in breast milk. It includes from about 100 to about 132 amino acids, has a deduced molecular weight of from about 10 to about 16 kDa, and has a deduced isoionic point of from about pH 10.1 to about pH 10.7. Antibodies and binding portions thereof recognizing the subject chemokine and peptides which include the antigenic portions of the subject chemokines are described. DNA molecules which encode the subject chemokines as well as nucleic acid molecules which, under stringent conditions, hybridize to nucleic acid molecules encoding the subject chemokines or to a complement thereof are also disclosed. The chemokines, peptides, antibodies and binding portions thereof, and nucleic acid molecules can be used to detect and treat breast disease, such as inflammations, infections, mastitis, benign cystitis, benign hyperplasias, cancer and other malignancies as well as other pathological states of the mammary gland.
L'invention concerne une chémokine isolée. La chémokine isolée est exprimée de préférence dans le tissu mammaire ou peut être détectée dans le lait maternel. Elle comprend 100 à 132 acides aminés environ, possède un poids moléculaire réduit compris entre 10 et 16 kDa environ et présente un point isoionique réduit compris entre 10,1 pH et 10,7 pH environ. L'invention concerne également des anticorps et des parties de liaison de la chémokine reconnaissant la chémokine objet de l'invention et des peptides comprenant les parties antigéniques des chémokines objets de l'invention. L'invention concerne aussi des molécules d'ADN codant les chémokines objets de l'invention ainsi que des molécules d'acides nucléiques qui, dans des conditions strictes, s'hybrident aux molécules d'acides nucléiques codant les chémokines objets de l'invention, ou à un complément de ces chémokines. Les chémokines, peptides, anticorps et parties de liaison de ces anticorps, et molécules d'acides nucléiques peuvent s'utiliser pour détecter et traiter une pathologie mammaire telle que des inflammations, des infections, une mastite, une cystite bénigne, une hyperplasie bénigne, un cancer et d'autres affections malignes ainsi que d'autres états pathologiques de la glande mammaire.
Dyster Lyn M.
Frustaci Jana M.
Papsidero Lawrence D.
Codon Diagnostics Llc
Gowling Lafleur Henderson Llp
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