Human chemokine beta-13

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2277580

The present invention relates to a CKbeta-13 (CK.beta.-13) protein which is a member of the chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK.beta.-13 protein. CK.beta.-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK.beta.-13 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

La présente invention se rapporte à une protéine CK.beta.-13 qui fait partie de la famille des chimiokines. Elle se rapporte notamment à des molécules d'acide nucléique isolées codant la protéine CK.beta.-13 d'origine humaine. L'invention concerne également les polypeptides de cette protéine ainsi que des vecteurs, cellules hôtes et procédés de recombinaison permettant de produire ladite protéine. Cette invention se rapporte en outre à des procédés de sélection visant à identifier des agonistes et des antagonistes de l'activité de CK.beta.-13. Enfin, cette invention se rapporte à des procédés diagnostiques permettant de déceler des troubles du système immunitaire et à des procédés thérapeutiques permettant de traiter de tels troubles.

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