Human chemokine polypeptides

Details Human chemokine polypeptides Human chemokine polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247113

Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Polypeptides chémokines humains et ADN (ARN) codant pour ces polypeptides chémokines, et mode de production de ces polypeptides au moyen de techniques d'ADN recombinant. On décrit aussi les méthodes pour utiliser ces polypeptides chémokines dans le traitement de la leucémie, des tumeurs, des infections chroniques, des maladies autoimmunes, des plaies et du psoriasis. Les antagonistes contre ces polypeptides chémokines et leur utilisation comme agents thérapeutiques pour traiter la polyarthrite rhumatoïde, les maladies inflammatoires et infectieuses autoimmunes et chroniques, les réactions allergiques, la fièvre indépendante des prostaglandines et les insuffisances médullaires sont également décrits.

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