Human chondromodulin-i protein

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/16 (2006.01) A61K 38/22 (2006.01) C07K 14/51 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2122937

- 70 - Abstract of the Disclosure: A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of said cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

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