Human chronic lymphocytic leukemia modeled in mouse by...

A - Human Necessities – 01 – K

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A01K 67/00 (2006.01) A01K 67/02 (2006.01) A01K 67/027 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2484920

Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals provide a useful animal model system for human B cell chronic lymphocytic leukemia.

La présente invention a trait à des animaux transgéniques contenant une séquence d'acides nucléiques codant pour la TCL1 liée en fonctionnement aux séquences de contrôle transcriptionnel dirigeant l'expression vers les cellules B. De tels animaux transgéniques fournissent un système animal modèle pour la leucémie lymphocytaire chronique humaine des cellules B.

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