Human cns receptors of the nmda-r1 family

Details Human cns receptors of the nmda-r1 family Human cns receptors of the nmda-r1 family

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2110934

ABSTRACT OF THE DISCLOSURE Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for EAA receptors of one family of human NMDA-binding type receptors has now been isolated and receptor proteins characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

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