Human coagulation factor vii polypeptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/64 (2006.01) A61K 38/48 (2006.01) A61P 7/04 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2461003

The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment. The variant comprises at least two substitutions; i) replacement of L305 and ii) replacement of at least one of the following amino acids selected from the groupconsisting of K157, k337, D334, S336, V158, E296 and M298.

La présente invention concerne des nouvelles variantes du facteur VIIa de coagulation humain ayant une activité de coagulation, ainsi que des constructions polynucléotidiques codant pour lesdites variantes, des vecteurs et cellules hôtes comprenant et exprimant ce polynucléotide, des compositions pharmaceutiques, des utilisations et des procédés de traitement.

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