Human coagulation factor vii variants

Details Human coagulation factor vii variants Human coagulation factor vii variants

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A01H 1/00 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 38/48 (2006.01) A61P 7/04 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) A61K 38/36 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2420892

The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses and methods of treatment. The variant comprises a substitution in at least one amino acid position, selected from the group consisting of positions Lys 157, Lys 337, Asp 334, Ser 336, Val 158, Glu 296 and Met 298.

La présente invention concerne de nouveaux variants du facteur VIIa de coagulation humaine ayant une activité de coagulation ainsi que des produits de synthèse d'acide nucléique codant de tels variants, des vecteurs et cellules hôtes comportant et exprimant un tel acide nucléique, des compositions pharmaceutiques, des utilisations et méthodes de traitement.

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