C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 38/48 (2006.01) A61P 37/06 (2006.01) C07K 16/40 (2006.01) C12N 9/52 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2343931
The present invention relates to the identification and use of a family of human complement C3-degrading polypeptides expressed by S.pneumoniae. The polypeptides have molecular weights of about 15 kD to about 25 kD or about 75 kDa to about 95 kDa, for example. Preferred polypeptides of this invention include the amino acid sequences of SEQ ID NO:2 and SEQ ID NO:5.
La présente invention concerne l'identification et l'utilisation d'une famille de polypeptides de dégradation du complément humain C3 exprimés par S.pneumoniae. Les polypeptides possèdent des poids moléculaires, par exemple, d'environ 15 kDa à environ 25 kDa ou d'environ 75 kDa à environ 95 kDa. Des polypeptides préférés de cette invention comprennent les séquences d'acides aminés SEQ ID NO:2 et SEQ ID NO:5.
Cheng Qi
Finkel David J.
Green Bruce A.
Hostetter Margaret K.
Masi Amy W.
American Cyanamid Company
Regents Of The University Of Minnesota
Smart & Biggar
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