Human complement c3-degrading proteinase from streptococcus...

Details Human complement c3-degrading proteinase from streptococcus... Human complement c3-degrading proteinase from streptococcus...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/52 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2283755

The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by S. pneumoniae. The proteinase has a molecular weight of about 24 kD to about 34 kD as determined on a 10 % SDS polyacrylamide gel. A preferred proteinase of this invention includes the amino acid sequence of SEQ ID NO:2.

L'invention concerne l'identification et l'utilisation d'une famille de protéinases dégradant la protéine C3 humaine du complément, exprimées par S. pneumoniae. La protéinase de l'invention a un poids moléculaire d'environ 24 kD à environ 34 kD, conformément à la détermination sur un gel de polyacrylamide à 10 % de SDS. La protéinase préférée de l'invention comprend la séquence d'acides aminés SEQ ID NO:2.

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