C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/48 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/52 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2305016
The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by S. pneumoniae. The proteinase has a molecular weight of about 15 kD to about 25 kD. A preferred proteinase of this invention includes the amino acid sequence of SEQ ID NO:2.
Cette invention se rapporte à l'identification et à l'utilisation d'une famille de protéinases dégradant la protéine de complément humain C3, qui sont exprimées par S. Pneumoniae. Une telle protéinase possède un poids moléculaire compris entre 15 kD environ et 25 kD environ. Une protéinase préférée de cette invention contient la séquence d'acides aminés ayant le numéro d'identification de séquence 2 (SEQ ID NO:2).
Cheng Qi
Finkel David J.
Green Bruce A.
Hostetter Margaret K.
Masi Amy W.
American Cyanamid Company
Regents Of The University Of Minnesota
Smart & Biggar
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