Human cystatin e

Details Human cystatin e Human cystatin e

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 31/70 (2006.01) A61K 38/57 (2006.01) A61K 48/00 (2006.01) C07K 14/81 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223888

Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

La présente invention concerne un polypeptide de CysE humaine et l'ADN (RNA) codant ce polypeptide, ainsi qu'une procédure de production dudit polypeptide par techniques de recombinaison. Elle concerne également des procédés d'utilisation dudit polypeptide dans le traitement de l'ostéoporose, de métastases tumorales, d'infections microbiennes, d'infections virales, de chocs septiques, d'inflammations, d'irritations de la rétine, de caries, de cachexie et d'atrophie musculaire. L'invention concerne également des méthodes de diagnostic permettant de détecter des mutations dans la séquence de codage et des modifications de la concentration des polypeptides dans un échantillon tiré d'un hôte.

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