Human cytomegalovirus neutralising antibodies and use thereof

Details Human cytomegalovirus neutralising antibodies and use thereof Human cytomegalovirus neutralising antibodies and use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/08 (2006.01) A61K 39/42 (2006.01) A61P 31/22 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2673755

Neutralising antibodies which are specific for human cytomegalovirus and bind with high affinity as well as immortalised B cells that produce such antibodies. The antibodies also have a high potency for the neutralisation of infection. Characterization of the epitopes that the antibodies bind to as well as the use of the antibodies and the epitopes in screening methods as well as the diagnosis and therapy of disease.

L'invention porte sur des anticorps neutralisants qui sont spécifiques au cytomégalovirus humain et qui se lient avec une affinité élevée, ainsi que sur des lymphocytes B immortalisés qui produisent de tels anticorps. Les anticorps de l'invention ont également une activité thérapeutique élevée pour la neutralisation d'infections. L'invention porte également sur les épitopes auxquels les anticorps se lient, ainsi que sur l'utilisation des anticorps et des épitopes dans des procédés de criblage de même que dans le diagnostic et la thérapie de maladies.

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