Human cytomegalovirus neutralising antibodies and use thereof

Details Human cytomegalovirus neutralising antibodies and use thereof Human cytomegalovirus neutralising antibodies and use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/08 (2006.01) A61K 39/395 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2730620

The invention relates to neutralising antibodies which are specific for human cytomegalovirus (hCMV), specifically the antibodies of the invention are specific for a combination of the hCMV proteins UL 128, UL130 and UL131A. Antibodies of the invention neutralise infection with high potency. The invention also relates to immortalised B cells that produce such antibodies, to the epitope that the antibodies bind to as well as the use of the antibodies and the epitope in screening methods as well as the diagnosis and therapy of disease.

L'invention concerne des anticorps neutralisants qui sont spécifiques pour les cytomégalovirus humains (hCMV); de façon spécifique les anticorps de l'invention sont spécifiques pour une combinaison des protéines de hCMV UL128, UL130 et UL131A. Les anticorps de l'invention neutralisent l'infection avec une puissance élevée. L'invention porte également sur des lymphocytes B immortalisés qui produisent de tels anticorps, sur l'épitope auquel les anticorps se lient ainsi que sur l'utilisation des anticorps et de l'épitope dans des procédés de criblage ainsi que le diagnostic et la thérapie des maladies.

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